Leptin Responsiveness of Mice Deficient in Corticotrophin-Releasing Hormone Receptor Type 2

Leptin Responsiveness of Mice Deficient in Corticotrophin-Releasing Hormone Receptor Type 2

Leptin acts centrally to inhibit food intake and increase energy expenditure. Corticotrophin-releasing hormone (CRH) is one of the neuropeptides that may contribute to leptininduced hypophagia and thermogenesis. Acute leptin administration increases CRH mRNA expression in the paraventricular nucleus of the hypothalamus and CRH receptor type 2 (CRHR2) expression in the ventromedial nucleus of th...

Leptin responsiveness of mice deficient in corticotrophin-releasing hormone receptor type 2.

Leptin acts centrally to inhibit food intake and increase energy expenditure. Corticotrophin-releasing hormone (CRH) is one of the neuropeptides that may contribute to leptin-induced hypophagia and thermogenesis. Acute leptin administration increases CRH mRNA expression in the paraventricular nucleus of the hypothalamus and CRH receptor type 2 (CRHR2) expression in the ventromedial nucleus of t...

Growth hormone response to growth hormone-releasing peptide-2 in growth hormone-deficient Little mice

OBJECTIVE To investigate a possible direct, growth hormone-releasing, hormone-independent action of a growth hormone secretagogue, GHRP-2, in pituitary somatotroph cells in the presence of inactive growth hormone-releasing hormone receptors. MATERIALS AND METHODS The responses of serum growth hormone to acutely injected growth hormone-releasing P-2 in lit/lit mice, which represent a model of ...

Inflammatory Responses 2-Deficient Mice Have Reduced Intestinal Corticotropin-Releasing Hormone Receptor

Physiological Roles Receptor Type 2 of Corticotropin -Releasing Hormone

Corticotropin-releasing hormone (CRH) is a key mediator of endocrine, autonomic, behavioral, and immune responses to stress. In response to stress, CRH released from the hypothalamic paraventricular nucleus (PVN) activates CRH receptor on the anterior pituitary corticotrophes, resulting in secretion of adrenocorticotropic hormone (ACTH) into the bloodstream. Two CRH receptors, CRH-receptor type...